Circular RNAs in Intervertebral Disc Degeneration: An Updated Review

Circular RNAs in Intervertebral Disc Degeneration: An Updated Review

Blog Article

Low back pain, a common medical condition, NEFF D95IHM1S0B 90cm Angled Chimney Hood Touch Control 700m³/h could result in severe disability and inflict huge economical and public health burden.Its pathogenesis is attributed to multiple etiological factors, including intervertebral disc degeneration (IDD).Emerging evidence suggests that circular RNAs (circRNAs), a major type of regulatory non-coding RNA, play critical roles in cellular processes that are pertinent to IDD development, including nucleus pulposus cell proliferation and apoptosis as well as extracellular matrix deposition.Increasing number of translational studies also indicated that circRNAs could serve as novel biomarkers for Water Hose Check Valve the diagnosis of IDD and/or predicting its clinical outcomes.Our review aims to discuss the recent progress in the functions and mechanisms of newly discovered IDD-related circRNAs.